In Bangladesh, school going children are treated with antihelmintics twice in a year. But many of the students complain that are reinfected before 6 months. So we need to know the minimum time that is required for reinfection.
I worked on Strongyloides stercoralis and I remember that STH reinfection could occur after 4 months of complete treatment
Given that you use albendazol, the half life of the drug is 8-12 hours, so theoretically, the children can get reinfected the very next day. Then, depending on the parasite, disease will manifest within weeks to months following reinfection.
Para evitar reinfecciones a corto plazo, lo ideal es hacer una abordaje integral, educación, construcción de letrinas y dotar de agua segura, por tres años continuos tratamiento con desparasitante y tratar de manera especial a los casos con infecciones severas.
it depend from the half-life of the drug and the risk of reinfection- it could be several weeks till we have a patent period again
This is a tough question. It will depend on the surrounding environment. If there is a super-infestation of infecting eggs in the soil, and the host (typically a child) goes barefoot, any protection given by the deworming treatment will start vanishing in the next few days and weeks. If the host is removed from all the risk factors (basically exposure to infected soils, precarious personal hygiene) it will take longer until the exposure occurs by accident. As Dr. Zuniga from Honduras stressed only an integrated approach may interrupt transmission and reinfections.
As it has been pointed out it depends on the drug half life. But once the drug is wiped out (usually 1-2 days later) reinfection could occur. Symptoms will start some weeks after the infection.
Hi Hossain, Soil-Transmitted Helmith reinfections occur rapidly after treatment. In reviews 3, 6, and 12 months post-treatment have been reported. Could be much earlier depending on the situation, but prevalence reaches upto 26% 3 months post treatment.
This probably can be a good paper for you: http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001621
Theoretically reinfection could occur usually after 1-2 days post-treatment (the drug half life). It depends on on both the hygienic conditions (presence or not of latrines, availability of safe water) and the hygienic habits (going barefoot, washing hands before eating, washing vegetables). Therefore, only an integrated approach of drug administration associated to improvement in hygienic condition and sanitary education may interrupt transmission and reinfections.
The meta analysis paper in PLOSntd on reinfection rate of STH after drug chemotherapy gave a good review of the success of control program against STH .
There is bound to be reinfection after drug treatment in endemic areas of STH infections.
The Japanese experience in eradicating STH esp. hookworm is exemplary. An effective step in controlling diseases is community participation and having a stake in the control programs. Community should help in building or providing toilets and educate themselves about transmission of the infections. Good and proper toilet usage will help in phasing out STH leading to eradication.
Hi
warm infestation and re infestation are a common problem difficult to eradicate without a solid eradication program including good hygiene otherwise re infestation takes place few days following the end of the treatment
Hi,
The antiparasitic medication is effective at particular stage of the parasite's life. The treatment with antiparasitic agents eliminates only that particular stage but does not affect other stage. Since the life cycle of parasites is complex having multiple stages and multiple sites, one drug may not eliminate all stages of parasites. Secondly, these drugs do not offer any prophylaxis against reinfection.
Theoretically, reinfection with parasite can occur at anytime irrespective of previous treatment.
The only way of prevention of intestinal infestation with parasites is good personal and food hygiene, sanitation and personal protection (eg foot wear to prevent infection with hookworms)
Periodic antiparasitic medication can only be one step in this direction by reducing the parasitic load in the host and population.
After treatment, STH reinfections occur rapidly particularly for A. T. And lumbricoides. Trichiura trichiura. Thus, regular administration of anthelmintic drugs is required to optimize the value of preventive chemotherapy. To interrupt STH transmission, integrated control strategies which emphasize health education and environmental sanitation are required.
”STH reinfections occur rapidly after treatment, particularly for A. lumbricoides and T. trichiura. Hence, there is a need for frequent anthelmintic drug administrations to maximize the benefit of preventive chemotherapy. Integrated control approaches emphasizing health education and environmental sanitation are needed to interrupt transmission of STH.” retrieved from Article Soil-Transmitted Helminth Reinfection after Drug Treatment: ...
It depends on the drug life, though it has been said that STH reinfections occur rapidly after treatment particularly for A. lumbricoides and T. trichiura, some studies/research 3, 6, and 12 months post-treatment have been reported.
The soil-transmitted helminths reinfections occur quickly after the treatment. It still depends on the drug half life. But once the drug is wiped out (usually 1-2 days later) reinfection could occur. Symptoms will start some weeks after the infection.
The minimum time of reinfection by STH to be a successful treatment depends on the half life of the drug and the different possible risk of reinfection that can occur to an individual. It can also depends on the environment and the way of living of an individual because if a person doesn’t change his/her lifestyle and environment the treatment will vanish.
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