The published material mentions minimum dose as 1 mg. Is 0.5 estradiol effective in reducing hot flashes and if yes ,after how many days does response occur ,clinically ?
In a randomized, double-blind, placebo-controlled, multi-center trial, lowest effective micro-dose of 0.014 mg per day for 17β-Estradiol applied transdermally was clinically and statistically significantly more effective than placebo in reducing the number of moderate and severe hot flushes in healthy postmenopausal women as early as 4 weeks of the study period (1).
1. Article Lowest Effective Transdermal 17β-Estradiol Dose for Relief o...
"Standard" doses of estrogen given daily, such as 17-beta estradiol (oral 1 mg/day or transdermal 0.05 mg/day) are adequate for symptom relief in the majority of women.
https://www.uptodate.com/contents/treatment-of-menopausal-symptoms-with-hormone-therapy#H3142916273
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