What is the minimal age for mouse model for Alzheimer (e.g. APPPS1 034832 - APP/PS1 Strain Details (jax.org)) to show neurodegeneration or at least placques?
will be 12 weeks enough? Do we need to focus on female samples?
In literature I have found 5 months, 3 months seem very early or am I wrong?
The most aggressive model for amyloid plaques is I believe the APPNL-G-F model, which first gets plaques at 2 months. Also the 5xFAD looks to get plaques as early as 2 months.
A great resource for comparing animal models in Alzheimer's disease is available on Alzforum (--> Research models --> Alzheimer's disease).
Development of plagues may depend on the model involved...what was used to induce the AD. But on average, 2-3months, earlier if it's genetically-induced.
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