Alessandro Crimi

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Questions related from Alessandro Crimi

What is the minimal age for mouse model for Alzheimer (e.g. APPS1) to show neurodegeneration or at least placques?

What is the minimal age for mouse model for Alzheimer (e.g. APPPS1 034832 - APP/PS1 Strain Details (jax.org)) to show neurodegeneration or at least placques? will be 12 weeks enough? Do we need to...

31 January 2023 1,250 3 View

Recent Sequence and structure of aptamers targeting PD-1 (immuno-oncology therapy)?

We are doing some in vitro computational chemistry. I would like to estimate good aptamers targeting PD-1. And would need to know the sequence and the ternary (possibly quaternary) structure from...

25 January 2022 3,823 0 View

Any difference between "hydroxy naphtol blue", and "hydroxy naphtol blue , disodium salt" for LAMP?

I am reproducing this work on LAMP (isothermal amplification) A new visually improved and sensitive loop mediated isotherm... , but I am a bit confused about the difference between "hydroxy...

01 September 2020 7,516 3 View

How do you to generate an animation based MRI tractography with stemming tracts?

HI, I am fascinated by this video made by James Stains from USC. https://www.youtube.com/watch?v=Eql5c4m_N68 It is a brain tractography from diffusion data, but he is able to show the tracts...

02 December 2019 2,103 3 View

Is more correct to do Image normalization by division or subtraction?

Hi all, I am creating an heatmap from gene expression in the brain using the allen brain atlas https://mouse.brain-map.org/ In practice I do a cumulative sum of gene level expression for a list...

01 January 1970 8,637 3 View