I have to work on hepatocellular carcinoma in rats or mice using any chemical method.
You can chemically induce using DEN (N-NITROSO-METHYL-ETHYLAMINE) and others to induce HCC. You can check out this paper.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741148/
Hi Nitin,
You can use our model of NDEA/DEN induced hepatocarcinogenesis (paper attached). This model works perfectly fine with rats. You can also download some more papers about the model from the researchgate page.
It might be helpful to chat with the folks at the Rat Resource & Research Center at the University of Missouri. I know they are available for consultation, but not sure how much experience they have with your model specifically.
http://www.rrrc.us/
Aflatoxin B1(AFB1) also induce HCC, but it induce hcc slower than DEN.
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