What is the mechanisms of anemia in leishmaniasis infections ?

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Aniruddha Ghosh

Please follow these references for your query....

Varma N, Naseem S. Hematologic Changes in Visceral Leishmaniasis/Kala Azar. Indian Journal of Hematology & Blood Transfusion : An Official Journal of Indian Society of Hematology and Blood Transfusion. 2010;26(3):78-82. doi:10.1007/s12288-010-0027-1.

Aikat BK, Mohanty D, Pathania AGS, et al. Hematological investigations in kala azar in Bihar. Indian J Med Res. 1979;70:571–582.

Woodroff AW, Topley E, Knight R, Downie CGB. The anaemia of kala-azar. Br J Hematol. 1972;22:319–329. doi: 10.1111/j.1365-2141.1972.tb05678.x.

Pippard MJ, Moir D, et al. Mechanism of anaemia in resistant visceral leishmaniasis. Ann Trop Med Parasitol. 1986;80:317.

Swarup-Mitra S, Chowdhary AK, Sarker M. Inhibition of some erythrocyte enzymes in kala-azar. Indian J Med Res. 1979;69:571–576.

Kasli EG. Hematological abnormalities in visceral leishmaniasis. East Afr Med J. 1980;57:634–640.

Hadi M. Hamza Al-Mayali

Thanks dear Ghosh

Sadiya aziz Anah

major factors contributing to the anaemia ,its haemolysis occuring in both massively enlarged spleen and liver and haemodilution resulting from expansion of the plasma volume and there was no evidence of significant ineffective erythropoiesis ,but a reduced plasma iron in the presence of great increased iron stores reticuloendothelial hyperplasia accompained by abnormal iron retention by macrophages typical of the anaemia of chronic disorders ,this may limit the erythropiotic response to anaemia in chronic leishmaniasis.

Asad Muyinda

Chronic Disease

Hypersplenism

Bone Marrow Infilitratio0n resulting in to DysErythropoesis

János Szlávik

Haemolysis, bone marrow infiltration, haemodilution, hypersplenia (enlarged spleen) are the main factors.

Thanks dear Janos

Biswajit Majumder

Hyperslenism.. Haemolysis,, anaemia of chronic disease, bone marrow depression, hamodilusion, malnutrition and rarely autoimmune haemolytic anaemia... You can follow the following links.. Thanks..

https://www.ncbi.nlm.nih.gov/pubmed/3026261

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002089/

http://www.jpma.org.pk/full_article_text.php?article_id=3382