Please I want to understand how expression of IL-6 control insulin sensitivity and glucose tolerance in humans.
Interleukin-6 (IL-6) is a cytokine that is closely associated with insulin resistance , impaired glucose tolerance because IL-6 impairs insulin signaling in part by down-regulation of IRS and up-regulation of Suppressor of Cytokine Signaling-3
Maybe the following papers will help you:
1. Carey, A.L. & Febbraio, M.A. Interleukin-6 and insulin sensitivity: friend or foe? Diabetologia (2004) 47: 1135. https://doi.org/10.1007/s00125-004-1447-y
2. Joseph J. Senn1, Peter J. Klover, Irena A. Nowak and Robert A. Mooney. Interleukin-6 Induces Cellular Insulin Resistance in Hepatocytes. Diabetes 2002 Dec; 51(12): 3391-3399. https://doi.org/10.2337/diabetes.51.12.3391
3. Iria Nieto-Vazquez, Sonia Fernández-Veledo, Cristina de Alvaro, and Margarita Lorenzo.Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle. Diabetes. 2008 Dec; 57(12): 3211–3221.
4. Toshinobu Suzuki, Junta Imai, Tetsuya Yamada, Yasushi Ishigaki, Keizo Kaneko, Kenji Uno, Yutaka Hasegawa, Hisamitsu Ishihara, Yoshitomo Oka, and Hideki Katagiri.Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-Cells.Potential Involvement of the PLC-IP3–Dependent Pathway.Diabetes. 2011 Feb; 60(2): 537–547.
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