What is the mechanism of IL-6 controlling insulin sensitivity and glucose tolerance?

More Emmanuel Ifeanyi Obeagu's questions See All

Can I consider the OOB score of RF model as the same as R^2 score?

In a topology optimization machine learning prediction algorithm, can I consider the OOB score of RF as the same as R^2 score. Could that be a more unbiased way of validating the model

14 February 2021 3,540 1 View

Can any scholar assist me with an r code for calculating average bias for each parameter of a continuous distribution via simulation?

I want to perform a simulation study to examine the consistency property of parameters of a new distribution through the quantile function. The simulation study will contain many replicates (say...

10 February 2021 180 3 View

Peer to Peer Lending in India?

Is there any recent work available on the performance of P2P Lending in India?

05 January 2021 5,211 3 View

How do I plot the correlation coefficients (r) on a map based on a list of variables?

I am working to improve a manuscript and I have been advised to provide a map showing where the correlation is significant. Any information or links to learn about this would be quite helpful....

26 December 2020 1,162 5 View

Why does water have high boiling point compare to ethanol?

Water is a molecule that has a very high boiling point compared to ethanol. Why does water have such a high boiling point compared to a molecule like ethanol, and what are the...

23 November 2020 9,662 8 View

Can someone recommend a blog or website where i can get the list of datasets used for Medical question answering?

I am looking for a website of blog where i can get details about the relevant datasets used for question answering in the medical field. What i found, are not explaining in details these...

10 November 2020 7,202 3 View

Impact of Microfinance?

Can anyone guide me to some recent studies on Impact of Microfinance in India on Poverty, Employment and Incremental Income. Many Thanks.

09 October 2020 9,962 1 View

Microfinance and Economic Activities?

What Economic Activities taken up with Microfinance loans can yield returns greater than 25% which is the usual cost of a micro loan in India?

09 October 2020 3,777 5 View

What are the benefits of Chelex method of DNA extraction over regular extraction method?

I will be extracting trypanosome DNA from mid-guts of tsetse flies for LAMP analysis. Kindly advice on protocol to adopt for maximum yield and benefits of Chelex method over the regular method....

23 September 2020 504 4 View

How do i use spatial displacement of nodes as displacement values in Abaqus?

I obtained the nodal displacement values of (u1,u2,u3) from a bar in an analysis. I want to use these spatial displacement values as the boundary conditions for the undeformed instance of the bar...

17 September 2020 7,793 3 View

How can i resolve the "final solutuin is not converged" error in Comsol for my heat transfer simulation??

I have been trying to simulate heat transfer problem in Comsol 5.5 for long time but it always throw an error stating: "Failed to find a solution. Maximum number of Newton iterations...

28 February 2021 8,626 3 View

Why do my MCFs not form monolayer?

Hello, I am looking for some expertise on culturing MCF7s. I purchased them from ATCC and I have been following all media and culture conditions. Media is EMEM with 10% FBS and 10ug/mL of...

27 February 2021 3,904 2 View

Fluo 3-AM in pancreatic beta-cells?

Dear all, I'm trying to understand if a molecule of my interest (capable of inducing glucose-stimulated insulin secretion) determines an increase in intracellular calcium levels in the presence of...

16 February 2021 453 2 View

Can anyone suggest a way to dissolve insulin which is for rat/mouse injection?

We are trying to inject insulin to rat or mouse, but the insulin we've got is powder, and there are many ways for dissolve, like in saline, PBS, DMSO, or in Tris-HCl, can anyone give us a...

13 February 2021 8,426 10 View

What is the possible cause of MSCs low growing?

Hello Everyone, We are inexperienced in culture of MSCs trying to grow a sample from BM of a mare. It is the second time that after preparation of new medium (DMEM-F12 with high glucose - 10% Hy...

07 February 2021 9,989 7 View

Bradford assay for insulin: discrepancies between standard curve and sample concentration during crystallisation?

Hi there, I would like to determine the unknown concentration of human insulin in my sample during crystallisation (the concentration range is roughly 0.5 -2 mg/ml, whereas the initial...

06 February 2021 9,370 7 View

Hi, Good day! Do you have related studies about my title, "Factors Affecting the Senior High School Students' Stress Tolerance in Problem Solving"?

I am new researcher. I want to learn more and I need your help. Thank you.

04 February 2021 6,834 4 View

Apricot database - where to search?

I work in apricot research and we have a breeding program for abiotic stress tolerance. I collect data from the cultivars i could use in this program individually, but there are several hundred...

01 February 2021 386 3 View

Need for help. What goes wrong with my differentiatio process of C2C12?

Hello, I'm now working on C2C12 myoblast cell line. Growing the cells was great, but there are some problems during differentiation process. The cells are not differentiating but frequently...

30 January 2021 9,535 2 View

Is there a protocol for the insulin encapsulation at physiological pH?

Hello everyone, I am going to start my master thesis on the encapsulation of insulin. In almost all protocols we found an acidic pH is necessary. Unfortunately, pH

27 January 2021 3,692 5 View

Entedhar Sarhat

Interleukin-6 (IL-6) is a cytokine that is closely associated with insulin resistance , impaired glucose tolerance because IL-6 impairs insulin signaling in part by down-regulation of IRS and up-regulation of Suppressor of Cytokine Signaling-3

Maybe the following papers will help you:

1. Carey, A.L. & Febbraio, M.A. Interleukin-6 and insulin sensitivity: friend or foe? Diabetologia (2004) 47: 1135. https://doi.org/10.1007/s00125-004-1447-y

2. Joseph J. Senn1, Peter J. Klover, Irena A. Nowak and Robert A. Mooney. Interleukin-6 Induces Cellular Insulin Resistance in Hepatocytes. Diabetes 2002 Dec; 51(12): 3391-3399. https://doi.org/10.2337/diabetes.51.12.3391

3. Iria Nieto-Vazquez, Sonia Fernández-Veledo, Cristina de Alvaro, and Margarita Lorenzo.Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle. Diabetes. 2008 Dec; 57(12): 3211–3221.

4. Toshinobu Suzuki, Junta Imai, Tetsuya Yamada, Yasushi Ishigaki, Keizo Kaneko, Kenji Uno, Yutaka Hasegawa, Hisamitsu Ishihara, Yoshitomo Oka, and Hideki Katagiri.Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-Cells.Potential Involvement of the PLC-IP3–Dependent Pathway.Diabetes. 2011 Feb; 60(2): 537–547.

Emmanuel Ifeanyi Obeagu

Thank you.