Many commercially available MS has "positive" and "negative" ion mode even the ones that use ESI. What is the mechanism for these? (by mechanism I mean electron impact ionization or or chemic ionization..)
some one asked this question before. See the link https://www.researchgate.net/post/What_is_the_difference_between_positive_ionization_mode_negative_ionization_mode_and_multiple_reaction_monitoring_MRM_mode