Dear all,
I am studying MHC-1 antigen presentation in response to different cellular stresses. In essence, a key aspect of my study is about proteasomal activity, alongside its different variants.
I appreciate that the constitutive proteasome and immunoproteasome generally have a similar structure with the exception of three beta subunits. I also appreciate that the immunoproteasome increases in prevalence after stimulation by interferon-gamma.
My question is
- How does the constitutive proteasome 'become' the immunoproteasome following stimulation by interferon gamma, ie how is there an increased predominance of the immunoproteasome?
- I assume a preferential synthesis of the B1i, B2i and B5i subunits and hence the effect is driven by differential transcriptional activity? If it is a transcriptional function, do we know the mechanism in which interferon gamma drives transcriptional factors for these genes?
Dear all,
I am trying to retrive from the "Los Alamos HIV sequence database" ONLY the sequence of HIV-1 POL for clade B. Would you be so kind as to tell me if this is possiible ? and if yes how to do it ?
Thank you very much,
Cecilia
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