What is the maximum percentage of PEG400 we can inject in mice IP?

18 January 2024 1 9K Report

I have to treat the mice with a drug that is dissolved in DMSO, but to decrease the percentage of DMSO I want to add PEG400 and cyclodextrin.

I would like to know the maximum recommended percentage that I can use of PEG400 when injecting IP in mice.

Malcolm Nobre

Hello Rasha Sl

PEG 400 is well tolerated in mice at a dose of 10mL/kg IP at 35% for 3 days or at a dose of 2.5mL/kg IP at 40% for 1 month. You may want to refer to the article attached below for more information. Please see Table 75 (PEG 400) under mouse species.

Article Tolerable Levels of Nonclinical Vehicles and Formulations Us...

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