What is the maximum duration for an antidiabetic activity study using STZ in wistar rats?

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Senthil Kumar A

There are studies performed for effect of STZ with 80 days, 22 weeks (Please find attached articles. But my opinion would be not more than 6 weeks, as the mortality rate would be high. Hence, 4-6 weeks would be optimum for treatment effect.

Revathi G

Antidiabetic study maximum duration 90 days