Alex Thomas

23 Questions 9 Answers 0 Followers

Questions related from Alex Thomas

While conducting Acute oral toxicity/ pathogenicity as per OPPTS885.3050.Untreated control groups are mandatory with all interim sacrifice groups?

Shelf control and untreated group at 21st day terminal sacrifice is enough? than keeping untreated group at all groups

04 August 2016 3,782 1 View

In guinea pig skin sensitization study, why acetone is insisted for challenge exposure if Test substance is water insoluble?

where as for induction 80% ethanol is insisted. Pls discuss Ref: OECD 406

09 July 2016 7,608 1 View

What type of plastic can with stand direct sunlight for a long duration(more than three years), when a garden pot is considered?

I need to know about suitable plastic which can withstand theseconditions without any cracks or damage

21 April 2016 2,104 3 View

When STZ induced diabetes in wistar rats are concerned, male or female is an ideal gender to perform?

We have administered 45mg/kg STZ, where male died first after few days females died

12 April 2016 9,333 6 View

What is the rat dose of Paracetamol that can be used for antipyretic activity if human adult dose of Paracetamol is 500mg ?

How that dose is derived and reference if any

12 April 2016 1,244 3 View

Does micropipette a right choice for administring test item to Rabbit eyes in toxicity studies?

Micropipitte tubes are sharp ended, pls advise if any othe choice is available

06 April 2016 5,378 2 View

Toxicology of Herbal extracts, which will be an ideal guideline and why?

22 March 2016 2,481 3 View

Why pH is not tested for oral toxicity studies?

pH is done for PSI, IMM but not for Oral

07 March 2016 441 2 View

On what basis OECD has kept acute toxicity study duration as 14 days?

01 March 2016 2,008 2 View

How can I calculate Cmax, Tmax, AUC, T1/2 in PK/PD studies?

Please find the data below: TIME IN MIN - 0, 30,60,180,300CON OF CURCUMIN in µg - 0.00, 7.66, 84.27, 40.87, 7.84 respectively

29 January 2016 9,529 6 View

Which type of statistcal analysis can be done for FOB (functional observational battery) data for sube acute toxicity study in Wistar rats?

Study Name : Sub acute toxicity Groups: 6 groups G1 control G2 low dose G3 mid dose G4 high dose G 1R control recovery (satellite group) G 4R high dose recovery (satellite group) observations...

25 January 2016 6,717 3 View

We have induced diabetes using STZ (40 mg/kg, I.P), But rats were died on 4th day of injection?

Protocol Species-Wistar albino rats No of rats-15 Body weight of rats-300-380gm Gender -M STZ- freshly prepared in citrate buffer,...

12 August 2015 5,733 11 View

How can I measure insulin levels in rat serum?

08 August 2015 780 2 View

How can I induce non-alcoholic fatty liver disease in a rat?

non alcoholic fatty liver disease

07 August 2015 7,435 5 View

Are toxicity studies required for functional foods?

we are developing a functional food , so would like to know whether sub- chronic toxicity study is required.

30 June 2015 1,230 17 View

Is an IVC system (individually ventilated cage) mandatory for animal studies(rats) ?

we have IVC system in our department, but facing the difficulty in handling rats and maintenance, as it can accommodate only 2 rats per cage. please anwser this question so that if not necessary...

30 May 2015 1,578 5 View

What are the points to considered, while working with ethanol induced hepatotoxicity in rats?

We are going to start a study on hepatotoxicity, please suggest ideal protocol and critical points to be considered.

28 April 2015 4,252 1 View

How many hours can we store blood mixed with EDTA before analysis (hematological analysis)?

17 April 2015 3,472 11 View

How to convert human dose to rat dose?

i have to do with anti ulcer activity of a hebal formulation human dose is 2ml for adult so what should it be for rats? .

14 April 2015 966 10 View

What is the maximum duration for an antidiabetic activity study using STZ in wistar rats?

can we plan a 90 day study using STZ 60mg/kg

14 April 2015 8,903 2 View

What should I consider while injecting STZ for inducing diabetes in rats?

Ideal dose of stz Glucose feeding Body weight Vehicle

07 April 2015 9,917 4 View

Is it possible to encapsulate oils in soft gelatin without oil spillage?

When we encapsulate oils in soft gelatin capsules, the capsules are getting coated with oil.

11 March 2015 5,078 3 View

Can anyone suggest a pharmacological screening method to compare activity of plant extract against uric acid and calcium oxalate stones in rats?

I would like to make a comparative study on the effect of a plant extract on uric acid and calcium oxalate stone in vivo.

05 March 2015 4,614 3 View