I want to give mice methanol extract from herbal, how much maximal volume of gaster for mice in mL, or how much volume can mice survive or adapt with methanol crude extract?
Dear Ricky,
The following is an abstract of a paper studied the gastric volume for mice and rats:
J Pharm Pharmacol. 2008 Jan;60(1):63-70.
Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments.
McConnell EL1, Basit AW, Murdan S.
Author information
Abstract
To use rodent models effectively in in-vivo investigations on oral drug and vaccine delivery, the conditions in the gastrointestinal tract must be understood. Some fundamental information is currently unavailable or incomplete. We have investigated the pH, water content and lymphoid tissue distribution along the gastrointestinal tract, as well as the stomach volume, as these were critical to our investigations on pH-responsive drug delivery and colonic vaccination. The observed values were compared with those in man as an indication of the validity of the rodent model. The mouse stomach pH was 3.0 (fed) and 4.0 (fasted), and the corresponding values in the rat were 3.2 (fed) and 3.9 (fasted). The mean intestinal pH was lower than that in man (
