muscle bulk is proportional to cartilage volume
exercise therapy==>increase intra articular IL10==>chondroprotective and anti inflammatory
exercise therapy increase muscle bulk that helps to weight bearing by the Joints. Usually disuse atropy of muscle found with OA due to pain.
Exercise continues to be the first line treatment for uncomplicated OA of the knee (AHCPR) for several reasons. We understand that joint motion stimulates a natural joint lubrication which is important and protective against joint erosion. When we exercise the muscles surrounding the knee we are improving the support system -both primary (ligamentous) and secondary system (muscular). Mechanical forces have been shown to be critical for mechanotransduction of not only bone/cartilage cells, but every cell type in the body (manuscript being published in ppmjournal.com) in September/October issue with more detail. Exercise also can help with weight management thereby reducing joint loads which can protect a fragile joint. Exercise is critical for development of prorioceptive or joint stabilization functions which are vital in protecting the joint during dynamic activities from further injury. Just some thoughts and good question.
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