This is a very interesting questions and unfortunately, as this is always the case in science, we can find different values in literature, ranging from 2 - 15 hours.
I hope, some more experienced colleague can shed more light onto this question.
I've attached some files and URLs, where I found these data.
http://link.springer.com/article/10.1007%2Fs002640000136
Dogan,
Thank you so much for your prompt response and for the links. It really looks like it is a difficult question to find the answer for. From what I understand from the links you suggested, it seems as the half-life of IL-6 is somewhere between 2 and 6h. The 15h suggestion is based on an in vivo response and there is probably a sustained production of this cytokine.
Thank you
Hi Giorgio,
I don't know if this will help, but we work with rat models and we were able to obtain high levels from tissues under resting conditions.
Good luck!
You're welcome Giorgio. And yes, you're right. I forgot to mention that half-times may vary between any experimental condition one chooses. I would also say that cytokines shouldn't have a very long half-time, especially in the case of IL-6, because of its pleiotropic effects.
I would like to share you and answer the question, telling that IL-6 life is between 2-6 hrs due to my experiences
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