What is the ideal depressurization rate for terminal sterilized ampoules?

21 June 2021 1 10K Report

During terminal sterilization of sealed ampoules, depressurization of the autoclave is needed and I'm asking about the depressurization phase safely without damaging the ampoules.

Thanks

Jorge Morales Pedraza

Perhaps it could be useful to read the following paper:

World Health Organization WHO Technical Report Series, No. 961, 2011 Annex 6 WHO good manufacturing practices for sterile pharmaceutical products.

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