It is a growth factor for hematopoietic stem cells

http://www.news-medical.net/news/2008/02/17/35295.aspx

Controlled by leptin, against diabetes.

http://www.eurekalert.org/pub_releases/2010-01/cp-lgc122809.php

Works against PTEN

http://www.news-medical.net/news/2008/10/20/42061.aspx

Other:

http://medicalxpress.com/news/2011-12-cancer-molecular-blood-vessels-trigger.html

Regards,

Joachim (not a medic)

IGFBP-2, the second most abundant IGFBP, is a member of a highly conserved family of six insulin-like growth factor (IGF) binding proteins (IGFBPs) that modulate IGF-I actions. This protein plays an important role in the regulation of several cellular processes such as proliferation, cell migration, and adhesion, all of which play key roles in cancer establishment and progression. The literature has been reported that IGF-binding protein 2 (IGFBP2) and IGF2 are expressed in the kidney, the cellular activities of IGFBP2 in this organ may have significant implications in diabetic nephropathy. Researchers have observed that IGFBP2 is normally expressed in less-differentiated fetal astroglial cells and that IGFBP2 expression is absent in mature cells.

I am please to send you these documents about your search:

http://www.endocrineconnections.com/content/1/2/95.full

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204033/

http://cancerres.aacrjournals.org/content/59/17/4228.full

Insulin-like growth factor-binding proteins and bone metabolism.

Conover CA.

Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E10-4. Epub 2007 Nov 14. Review.

PMID: 18003717 [PubMed - indexed for MEDLINE] Free Article

Related citations

Try to look at publications of Prof. Conover, she is a specialist in this field.