The antimicrobial effect of local anesthetics has been known for more than 50 years, but it still seems to have an unclear mechanism of action. which bacteria? which concentration? etc etc. . Where can I find more literature?
some anesthetics like procaine and benzocaine have the ability to generate oxidative stress via oxidizing free radicals. Common knowledge about these drugs. - Oxidative stress caused by amino ester anesthetics might be antiseptic toward common skin or mucosa flora just like Oxygen Water (hydrogen peroxide) and thus antimicrobial. Just a thought