Mechanical processes used in the pharmaceutical industry like mixing and milling. Such processes have an effect on the bioavailability of these drugs. What is the effect of dicarboxylic acid if mxed or co-milled with the drug during its manufacture?
Harita Desai
The mixing or comilling of a drug with dicarboxylic acid leads to interaction between the two by means of various forces like hydrogen bonding, vander waals etc. One of such interaction results in formation of cocrystal which shows changes in the inherent features of drug i.e. crystallinity, stability, solubility etc. The extent of change depends on the pharmaceutical profile of the acid in concern.
The interaction is governed by the energy changes involved in the respective processes.
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