Ramy Elsergany

13 Questions 21 Answers 0 Followers

Questions related from Ramy Elsergany

What is the effect of some dicarboxylic acids like adipic acid on the amorphous content of certain drug exposed to energetic mechanical processes?

Mechanical processes used in the pharmaceutical industry like mixing and milling. Such processes have an effect on the bioavailability of these drugs. What is the effect of dicarboxylic acid if...

22 May 2014 9,034 1 View

Why does Invirase (saquinavir mesylate) have less bio-availability than Fortovase (saquinavir) from a formulation point of view?

In some cases, we add rotinavir to invirase to enhance the bioavailability of invirase.

05 May 2014 8,978 2 View

What is the formulation approach used to minimize the variable bioavailability of cyclosporine as an immuno-suppressant drug?

Ciclosporine is a cyclic peptide formed of 11 amino acids having a molecular weight of 1200.

28 April 2014 6,609 2 View

Why does charcoal from different manufacturers have different adsorption capacities?

Adsorption Isotherm.

22 April 2014 3,224 2 View

What is the role of P-chart as SQC in ensuring good quality of a pharmaceutical product?

Statistical quality control.

19 April 2014 2,877 4 View

What is the most important US pharmacopeial test for PVP?

Particularly from formulation point of view?

13 April 2014 9,135 1 View

Why does paracetamol need a certain moisture level and binder concentration for good compression into a tablet?

With acceptable hardness and friability.

06 April 2014 1,599 4 View

What is the possible formulation approaches for reduction of the Hepato-toxic side effect of nimesulide?

The metabolite of nimesulide is of known hepatotoxicity.

03 April 2014 2,959 2 View

What is the difference between dosage form and drug delivery?

Suggest an example

03 April 2014 839 3 View

Why does the amorphous form of drug have better bioavailability than crystalline counterparts?

For example, in some applications.

03 April 2014 6,663 8 View

How to improve the disintegration for Microcrystalline cellulose pellets prepared by extrusion and spheronization?

Particularly for BCS class II drugs such as NSAIDs

30 March 2014 7,026 6 View

Do the physicochemical properties of drugs affect the blending uniformity?

Direct compression.

25 March 2014 8,629 5 View

Does the moisture content of API not need to be changed even after wet granulation and further drying process?

see above

22 March 2014 914 2 View