How do antibiotic-loaded nanoparticles influence the growth, survival, and resistance mechanisms of multidrug-resistant (MDR) bacteria, and what advantages do they offer compared to conventional antibiotic therapies?
Antibiotic-loaded nanoparticles enhance the effectiveness of antibiotics against multidrug-resistant bacteria by disrupting resistance mechanisms and enabling targeted, sustained drug delivery. They offer improved antimicrobial action, lower side effects, and reduce the risk of further resistance compared to conventional therapies.
Hi !
Antibiotic-loaded nanoparticles enhance antibacterial efficacy by improving drug solubility, ensuring sustained release, and facilitating targeted delivery that penetrates bacterial biofilms and intracellular reservoirs, thereby reducing minimum inhibitory concentrations against multidrug-resistant (MDR) strains. They can bypass traditional efflux pumps, disrupt cell membranes, and induce oxidative stress, ultimately lowering resistance development compared to conventional therapies. Furthermore, their surface functionalization allows synergistic co-delivery and immune modulation, offering superior therapeutic outcomes over standard antibiotics.
Reference(s) in support:
Article “Nanoantibiotics”: A New Paradigm for Treating Infectious Di...
Article Nanotechnology as a therapeutic tool to combat microbial resistance
Article Nanoparticle-based targeted drug delivery
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