Greetings everyone. Please I am running a research on splenomegaly and I have a problem of the drug that can be used to induce splenomegaly.
I have seen Chemotherapeutic drugs but wasn't giving the information needed for inducing splenomegaly in Wistar Rat
Splenomegaly results from different abnormal conditions susceptible to drugs. Their diagnosis is based on a history of exposure to a drug before the spleen enlargement. Drugs may provoke the enlargement of the spleen by a direct effect on splenic cells or as a side effect of disturbances in other organs, such as the liver, or systems, such as the haematoimmunological system. Some drugs provoke severe haemolysis associated with splenomegaly. Another cause of spleen increasing in size is the venous congestion due to liver disturbance with portal vein occlusion as side complications of drugs. All these drug side effects are usually transitory and splenomegaly disappears when the medication is discontinued.
Splenomegaly results from different abnormal conditions susceptible to drugs. Their diagnosis is based on a history of exposure to a drug before the spleen enlargement. Drugs may provoke the enlargement of the spleen by a direct effect on splenic cells or as a side effect of disturbances in other organs, such as the liver, or systems, such as the haemato immunological system. Some drugs provoke severe hemolysis associated with splenomegaly. Another cause of spleen increasing in size is the venous congestion due to liver disturbance with portal vein occlusion as side complications of drugs. All these drug side effects are usually transitory and splenomegaly disappears when the medication is discontinued. By Promit Ananyo Chakraborty I agree with this deep and focused explanation what drug induced splenomegaly means
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