Tumor suppressor genes are wild-type alleles of genes that play regulatory roles in cell proliferation, differentiation, and other cellular and systemic processes. Their loss or inactivation has oncogenic effect in the cell cycle. Examples P53, Rb. Antitumor suppressor genes. Antitumor suppressor are group of genes that cause normal cells to become cancerous when they are mutated. They antagonize the function of tumor suppressor genes. Examples includes mutant forms of Ras, Myc, GFRs, Bcl-2 etc