According to 2002/657/EC, minimum required performance limit (MRPL) means minimum content of an analyte in a sample, which at least has
to be detected and confirmed. It is intended to harmonise the analytical performance of methods for substances for which no permitted limit has been established.
My question is:
(1) In the case of substances for which no permitted limit (e.g., MRL) has been established, how do I establish the minimum required performance limit (MRPL)? And, what is the difference between MRPL and detection capability (CCβ) of substances for which no permitted limit has been established?
MRPL is not determined by analysts, it is an official value set by authorities, just like MRL. From analytical point of view, it means that you must be able to detect the compound at this level, so your CCbeta must be lower or equal to MRPL.
At the moment only few MRPLs are set:
Chloramphenicol 0,3 μg/kg
Medroxyprogesterone acetate 1 μg/kg
Nitrofuran metabolites 1 μg/kg:
— furazolidone
— furaltadone
— nitrofurantoin
— nitrofurazone
Sum of malachite green and leucomalachite green 2 μg/kg
For some compounds that are not approved to use but do not have MRPLs, reference values were set by EU-RLs.
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