Bin Guo

5 Questions 23 Answers 0 Followers

Questions related from Bin Guo

How to quantify an intact protein by multiple reaction monitoring?

According to some recent reports, several intact proteins,just like small-molecule compounds, can also be measured by LC-MS/MS with MRM mode. How to obtain and select the marker fragment(s) and...

05 May 2016 3,426 1 View

What is the difference between MRPL, CCα and CCβ?

According to 2002/657/EC, minimum required performance limit (MRPL) means minimum content of an analyte in a sample, which at least hasto be detected and confirmed. It is intended to harmonise the...

01 January 2015 3,837 3 View

Is there any difference in dispersive solid-phase extraction (DSPE), solid-phase dispersive extraction (SPDE) and matrix solid-phase dispersion(MSPD)?

Bio-sample preparation

08 August 2014 8,449 4 View

Is it possible to measure other small-molecule analytes in complex matrices by MS-based strategy without reference standards?

Recently the low-flow or nanospray mass spectrometry has emerged as an attractive approach to standard-free quantification of drug metabolites.

09 September 2013 7,966 7 View

How does one separate the proteins adsorbed on gold nanoparticles and measure the enzymatic activity?

We recently have found that nanoparticles can inhibit enzymes. But we don't know the exact mechanism and whether it is an irreversible inhibition or not.

07 July 2013 2,730 11 View