I am an undergraduate student currently using a HFD Mouse model to examine ER stress in various tissues implicated by type 2 diabetes. However I have noticed some papers use db/db mice ( C57BL/6J ) to examine ER stress in type 2 diabetes. I am just wondering what the difference between HFD vs db/db is? What are the pros and cons of each model?
Both high-fat-diet-induced obesity model mice and db/db mice show much the same phenotype of metabolic syndrome and type-II diabetes mellitus.
As compared with HFD mice, db/db mice more significantly exhibit the peripheral neuropathy, cardiomyopathy, and impaired beta-cells secreting insulin.
The db/db mouse model has a deficient leptin receptor.
Metabolism. 2000 Jan;49(1):22-31.
The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding.
Kobayashi K1, Forte TM, Taniguchi S, Ishida BY, Oka K, Chan L.