You can use a desiccator to keep a dried sample dry, but don't use it to dry your enzyme solution. In a desiccator it would take a long time for your sample to dry, and in all likelihood the protein would denature or at least lose activity.

Since the protein is kept cold while using a freeze dryer the protein is much more likely to keep its activity.

Watch your buffer when using a freeze drier though. For example a sodium acetate buffer will loose its acetate (as acetic acid) and turn into a strong base, potentially denaturing your sample. Stay away from volatile buffer substance, unless you can use ammonium acetate or ammonium carbonate (which evaporate completely).

Thanks Holger for your guidance.

Hi there,

dessicator is used for dehydration and freeze dryer is used to eliminate any volatile molecule from your sample including water. So as mentioned above, concerning an enzyme I would go for freeze drying...

The prefreezing sample