Following CRISPR mutagenesis and sequencing analysis of the F1s, I have found a heterozygous male with 10bp deleted on exon1 and a heterozygous female with 5bp deleted on exon 1. I was wondering if there is specific term that would be applied to F2 offspring that would inherit both these mutations, because this is not homozygosity. Thank you.
It seens like compound heterozygous...... but these are deletions......
yes that is ok you can have alleles with insertions, deletions, point mutations or any change really but heterozygous is a general term that can be used to describe any 2 (or more if appropriate species) different alleles even if one allele were completely deleted in which case you could be heterozygous for normal/null alleles
In your case, compound heterozygous. If the mutations are in different genes, then its called double heterozygous.
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