The UKPDS Outcomes 2 Arm suggests the importance of tracking and monitoring the WCC in the prediction of diabetes complications development. Please explain?
Hi Jill. Diabetes is an inflammatory disease. There is no doubt about it! Of course, if there is no underlying infection, inflammation must be involved in other processes. One idea: white cells are "participating in inflammation-induced disorders of metabolism". I recommend you to read this article: http://www.hematology.org/Thehematologist/Diffusion/1110.aspx
Have a nice day!
Hi, Jill. As Romina said, the role of inflammation in the development of diabetes mellitus, diabetes-related complications and diabetes-associated risk factors (e.g. obesity or depression) is well known. There is a increasing number of research and publications on this topic. Following there are the links to recently published reviews:
http://dx.doi.org/10.1111/j.1365-2249.2011.04501.x
http://dx.doi.org/10.3389/fendo.2013.00068
http://dx.doi.org/10.1016/j.neubiorev.2011.10.001
The first to articles are free available, the third one I attach as pdf file.
Kind regards, Michael
UKPDS was a prospective diabetic study carried out in the UK over a period of 2 decades. The facts that it was prospective, multicentre (conducted in over 20 clinical sites) and on human subjects lent credence to its validity. Yes, chronic inflammation plays a role in the development of type2 DM, but this is usually in the context of other favourable conditions namely insulin resistance and high BMI (overweight or obesity). Interestingly, these factors are present in significant proportion of type 2 DM patients. If this is so, one possible link would be the increased production of inflammatory cytokines associated with impaired lipid metabolism in the obese. Again, because DM is a multi-systemic disorder with increased tendency to acquiring infections as a result of lowered immunity, monitoring white cell counts early in patients with this metabolic disease may not be a bad idea.
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