Do cannabinoids have a trancription-specific effect only or do they also affect other processes in the cell?
Cannabinoids are a group of compounds present in Cannabis plant. They mediate their physiological and behavioral effects by activating specific cannabinoid receptors. The cannabinoid receptors are:
– CB1 (Primarily found in CNS neurons)
– CB2 (Primarily found in PNS immune cells)
– CB-vanilloid (Primarily studied in CNS neurons – Vanilloid type one or VR1)
– abn-CBD (Primarily found in endothelial cells of blood vessels)
They induce growth arrest or apoptosis in a number of transformed neural and non-neural cells in culture. Cannabinoids have the ability to inhibit DNA binding of three major families of nuclear transcription factors: CREB/ATF, AP-1(Fos/jun) and NF-KB/REL. They are well established as being immune modulations.
I am pleased to send you this link that probably can help you with your search.
http://www.druglibrary.org/crl/immune/Kaminski%2098%20cAMP%20Cascade_%20JNeuroimmunol.pdf
Please receive other information about Cannabinoids .
http://www.advancedholistichealth.org/PDF_Files/Benificial%20Effects%20in%20Immune-Mediated%20Diseases.pdf
Thanks so much for the information, Yanick. So, I suppose that their effects are transcription-targeted and therefore they should function in relatively little time after delivery, right?
I meant that since they target transcription factors their effects should be expected fast upon administration to cells (within a dew hours?).
Many endocannabinoids are synthesized from arachidonic acid, I believe. Maybe that could help...
According to the literature that’s right. However I don’t find yet the exact time. I send you this attach about your search which probably be helpful.
http://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1150&context=stein
Cannabinoids act at cannabinoid receptors on the membrane, which are G protein-coupled receptors that are coupled generally to the Gi subtype of G protein and the negative regulation of adenylyl cyclase and cAMP. Of the two known cannabinoid receptors, CB1 and CB2, the CB1 receptors are abundant in the brain and are located predominantly, although not exclusively, on axon terminals, where their activation by cannabinoids causes the suppression of neurotransmitter release. This is a rapid action that does not require gene transcription or interaction with transcription factors.
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