Dear Mahesh,

Diazepam has a solubility in water of 0.05mg per mL so it is not really soluble. Soubility improves with othere solvents :41mg per mL in 95% ethanol and 17mg per mL in propylene glycol. 

I hope this help,

Best of Luck

Dom

Diazepam, a benzodiazepine drug, can be somewhat challenging to dissolve due to its poor solubility in water. However, there are effective methods for dissolving Diazepam for experimental or pharmaceutical applications. Here's a general approach:

Note: The exact method may vary depending on the specifications provided by the manufacturer (Sigma, in your case) and the intended use of the solution. Always refer to the product data sheet and safety instructions provided by the manufacturer. If the solution is intended for biological applications, ensure that the solvent and its concentration are compatible with your biological system.

l With this protocol list, we might find more ways to solve this problem.