Levofloxacin and moxifloxocin are commonly used. I am not sure which one will cross BBB better.
FQs as such can cross BBB, levofloxacin has been proven to be better along with the regimen.
However ADRs are part of the play.
I feel drug which is more of lipophillic in nature, would cross the BBB.
I agree with previous comments. Moxifloxacin is reported to possess highest in vitro activity against M.Tb. So if csf levels are monitored and achieved it is a good second line agent. Also, it has been suggested in the article below that a moxifloxacin dosage of 800 mg once per day can avoid resistance (Gumbo T et al,. Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modeling. J Infect Dis 2004;190(9):1642-51). So moxifloxacin or levofloxacn may be useful as second line agent if any of the drugs in first line cannot be used.
- Badges
- Science topic
- Similar topics
- Medicine
- Disease
- Infectious Diseases