NCEAP ATPIII and various guidelines point out that LDL/HDL is an important predictor of atherosclerosis. But in clinical practice I found that log of TG/HDL (Atherogenic index of plasma) as an important marker in South Asians.
It is clear that genetic factors associated with different populations may cause the prevalence of abnormal lipid metabolism. In this sense, the index LDLc / HDLc is widely used as an indicator in Caucasian populations, however I do not think much of it because the LDL is just a poor (truly atherogenic) indicator of the number of LDL particles, HDL-C not informs us about its functionality. Since HDL-C and triglycerides are inversely related through the activity of CETP, may offer the relationship has a certain sense. Have you consistent information about this relationship (logTG / HDL-C) as an indicator of CVD risk in Asian population?
We do observe this relationship in patients with cardiovascular events. At the moment doing a small hospital based study among stroke patients comparing LDL/HDL vs AIP
Due to the presence of dysfunctional HDL particle in some populations like postmenopausal women, I prefer ApoB I Apo A.I ratio because Apo AI shows antioxidant propertes by itself.
I am of the same view as expressed nicely by Dr. Regina Wikinski . Thanks
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