Several chemical agents can induce liver cancer in rats as DEN, aflatoxin B1, but after several weeks. Is there is another chemical agents or method can induce liver cancer in rats after short time?
You can induce HCC at faster rates when DEN and Phenobarbitol are used in combination.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741148/
Methods
Rat Novikoff hepatoma cells were injected percutaneously into the liver lobes of Sprague-Dawley rats under the guidance of high resolution ultrasound. A similar induction procedure was performed by means of laparotomy in a different group of rats. Ultrasound-guided implantation of Novikoff hepatoma cells led to the formation of orthotopic hepatocellular carcinoma in 60.4% (55/91) of the Sprague-Dawley rats.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741148/
Dear Aymn, there are a number of different protocols of HCC induction. You can find relevant information in the following papers
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741148/
http://www.ncbi.nlm.nih.gov/pubmed/22025031
Dear Aymn, You can find many information in the following papers
Int J Exp Pathol. 2009 Aug; 90(4): 367–386.
doi: 10.1111/j.1365-2613.2009.00656.x
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