We want to measure any bacterial product in human plasma, since translocation of bacterial material to blood occurs in several conditions, like HIV infection. However, we get very contrasting opinions on their utility and their feasibility. We would like something representative (specific) of bacterial translocation, and techinaclly feasible.
Hello. Really, contrasting opinions as study results contrasting also. In case of a gut, the bacterial components translocation depends on many factors (local and system). What do you think about use of bacterial scintigraphy?
Sincerely. Zmicer.
This discussion can be interesting: http://onlinelibrary.wiley.com/doi/10.1002/hep.24303/pdf
Sincerely, Zmicer
Very interesting manuscript, Zmicer. Thanks!
I've been reading opinions that high blood LPS in obese (endotoxemia) is due to LPS carry on with lipids, this, based on the observation that orlistat treatment (lipase inhibitor that lowers fat absortion) decreases LPS levels in these patients. If that were the case, we should expect high LPS and low bacterial DNA. The mechanism of bacterial translocation in HIV infection seems to be very different (quite independent of obesity) Brenchley 2006 Nat Immunol, and bacterial DNA can be found in blood of these patients (Jiang). I will provide the citations in a next post.
Dear Enrique
I `m suggesting to consider the expression of TLRs and the suppressor of SOCS-3 in mononuclear cells for more specific detection. An increase in their expression is expected but the level of expression need more study.
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