Hi

In related to first question, the following article may be helpful.

Regards

Many thanks!

The best model  will be primate monkey

We published a protocol model of CNV in mouse which mimics AMD.

https://www.researchgate.net/publication/258055788_Laser-induced_choroidal_neovascularization_model_to_study_age-related_macular_degeneration_in_mice

This model is rapid, reproducible and ethically acceptable in contrary to primate model.

Article Laser-Induced choroidal neovascularization model to study ag...

Many thanks, Does the age of the mice relevant?

It's better with mice between 6-8 weeks. But slightly older is also good.

But your control group should absolutely has the same age.

great thanks