All VHF cases are always malaria positive? I am not sure. Do you have enough data to support this hypothesis?

Dear Aradaib. I would also raise the same point as done by Sumodan.

Dear Sumodan and Khalid

I am still looking forward to hear from somebody who has been experiencing the same situation

Do you thing it is associated with the immunosupression?

VHF cases are certainly not always malaria positive – if that were true then there would not be cases of CCHF in Europe or northern Asia. However, this is definitely an interesting (and underresearched) area.

Ebola screening in West Africa at present has a malaria lateral-flow test performed concurrently - these statistics are not publically available as the malaria screen is informative rather than for diagnostic purposes. The majority of Ebola positive cases are malaria negative, but it does appear that cases of Ebola/malaria co-infection are more likely to end in a fatal outcome. If this is a genuine trend it could bias experiences of small VHF outbreaks - coinfection leads to more severe cases and severe cases are more likely to tested which would give the impression that most/all cases are both VHF and malaria positive.

It seems logical that any underlying infection that weakens the immune system will increase the likelihood of developing a symptomatic VHF infection if exposed (infectious doses + the level of asymptomatic infection are also underresearched areas for most/all VHFs) and for that infection to end in a fatal outcome, so being malaria or HIV positive when exposed to a VHF virus is not likely to end well. However, at present we do not have enough data to make firm hypotheses. I am sure that someone will analyse the association between malaria/Ebola co-infection and the change in case fatality rate when compared to Ebola only infections once the outbreak has ceased - at the present though all efforts are focused on providing assistance in the affected regions

Symptoms of headache, fever, and malaise are also often associated with infections such as malaria, which may be endemic to regions where the viral hemorrhagic fevers occur. Treatment of viral hemorrhagic fevers is very limited, and containment of the infections is often the only means available to prevent spread.

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Hemorrhagic Fever - an overview | ScienceDirect Topics