I don't think there has been any effective vaccine for schistosomes yet. All the tested candidate vaccines have rather been poorly immunogenic or at best moderately immunogenic (40-45% efficacious). One of the new strategies in schistosome vaccine formulations is improving the vaccine delivery routes using nanotechnologies. This technologies has improved the efficacy of schistosome DNA vaccines. I think the reason why we are yet to recall success stories on schistosomes vaccine is due to lack of interest on the part of researchers in the field as witness for malaria and other infectious agents. RTS'S, a malaria vaccine has got to the certification stage, however, for schistosomiasis to the best of my knowledge we are still at the preclinical stage.
There is no commercially available vaccine against schistosomiasis. However, there have been ongoing efforts to develop one. Several vaccine candidates have shown promise in preclinical and early clinical trials.One of the most advanced vaccine candidates is the Sm-p80-based vaccine, which targets Schistosoma mansoni. Sm-p80 is a protein involved in the penetration of schistosome larvae through host skin. Experimental trials of this vaccine have shown significant reductions in parasite burden and protection against infection in animal models. Clinical trials in humans have also demonstrated safety and some degree of efficacy, but further research is needed to optimize its effectiveness.Other potential vaccine candidates include antigens derived from other stages of the schistosome life cycle, such as cercariae and adult worms. These vaccines aim to stimulate the host immune system to produce protective antibodies and immune responses that prevent infection or reduce parasite burden upon infection.
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