I have prepared a polymer-drug nanoparticles using self assembled technique and achieved ~ 60 percent drug loading efficiency. Is this considered good?
Dear Nor,
In self assembled technique 60% loading efficiency is considered very good. For example the following paper entitled "A novel self-assembled targeted nanoparticle platform based on carboxymethylcellulose co-delivery of anticancer drugs " by Lin Dai,a Ke-Feng Liu,a Chuan-Ling Si,b Jing He,a Jian-Du Lei*a and Li-Qun Guoc published in J. Mater. Chem. B, 2015,3, 6605-6617 have designed and synthesized a new targeted nanoparticle platform for co-delivery of two different anticancer drugs
using self assembled technique and achieved drug loading efficiency ∼23 wt% for the first drug (BA) and 21.15 wt% for the second drug (HCPT) and they consider this loading efficiency as good:
Paper A novel self-assembled targeted nanoparticle platform based on carboxymethylcellulose co-delivery of anticancer drugs
Lin Dai,a Ke-Feng Liu,a Chuan-Ling Si,b Jing He,a Jian-Du Lei*a and Li-Qun Guoc
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J. Mater. Chem. B, 2015,3, 6605-6617
DOI: 10.1039/C5TB00900F
Received 13 May 2015, Accepted 13 Jul 2015
Single-drug therapy for cancer is greatly hampered by its non-specific delivery to the target tissue, limited efficacies, poor tolerability, and resistance profiles. In order to overcome these limitations, we developed a new targeted nanoparticle platform for co-delivery of two different anticancer drugs. A conjugate based on carboxymethylcellulose (CMC) was first synthesized by introducing hydrophilic molecules (PEG), target molecules (folate), and drug molecules (betulinic acid) into CMC. Then another anticancer drug hydroxycamptothecine (HCPT) was encapsulated into the nanoparticles from the conjugate using a simple nanoprecipitation method. The obtained nanoparticles possessed appropriate size (∼180 nm), high drug loading efficiency (∼23 wt% BA, 21.15 wt% HCPT), a slow drug release rate, higher blood circulation half-time of free BA (6.4-fold) and HCPT (6.0-fold), and high synergetic activity of BA and HCPT toward cancer cells. Furthermore, the targeted nanoparticles showed rapid cellular uptake by tumor cells. The antitumor effect of the nanoparticles in a mouse tumor xenograft model exhibited a much better tumor inhibition efficacy and fewer side effects than that of BA and HCPT, strongly supporting their application as efficient carriers for anticancer therapy.
http://pubs.rsc.org/is/content/articlelanding/2015/tb/c5tb00900f#!divAbstract
https://www.researchgate.net/publication/280062995_A_novel_self-assembled_targeted_nanoparticle_platform_based_on_carboxymethylcellulose_co-delivery_of_anticancer_drugs
Hoping this will be helpful,
Rafik
Article A novel self-assembled targeted nanoparticle platform based ...
Dear Rafik, thank you for the explaination and the references. really helpful.
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