u can go for DMSO OR mixture for of DMSO & Methanol..

I agree with Atul, then the product can be isolated by pouring the reaction mixture into crushed ice.

what is your amine name? try to soluble it in dichloromethane , toluene or DMF .

Methanol/Ethanol worked fine but since your amine is soluble in DMSO, you may use a combination. You may tried neat reaction in the presence of activated 4A molecular seives.

Hi

I am agree with ramesh. The best solvent is dry methanol

Hoq,

You have gotten answers, what did you find out in the lab? It is good idea that you give the contributors your feedback from your lab work.  I see  Pazdera' answer is a good one and I hope that it did work for you.

Good luck

The best silvent for imine formation is aqueous ethanol .

I would try AcOh/ Py 1:1 mol/mol 60 degrees, or EtOH aq (25/30) at the same temperature....another chance would be MeOH with 1% DIPEA still at 50-60 degrees...

You can try in dry toluene, but it depends of the starting materials

MeOH，THF, WATER AND SO ON

I need help please. I try to prepare shifft base by reaction 2,9-dibuthyl-1,10-phenanthrolin,5-6-dione with 1..2-aminoethanthiol. 2...L-analyne. 3..Glycine. I used ETtOH absolute with reflux 6-8 h but no results. My Q can I use the reaction in G. AcOH as solvent or no .because amine did not dissolve in alcohol but it dissolves in water. Thanks in advance

In my opinion, it is better to avoid DMF/DMSO. because it is difficult to remove from the system. You can use ethanol, methanol, dioxan, toluene but not as single solvent . Depending on the reagent, use can try with different proportion of solvent. if it is not working add small amount of DMSO/DMF, then reflux, then it will become soluble very slowly.

Protic solvent is the best solvent for imine formation.

May be you can useful from the following article

Try with Acetic acid , or EtOH with 2-3 drops of HCl

Try with DMF : Methanol mixture (10:90) mixture

Aqueous Ethanol can be the best.

The best solvent for imine formation is aqe. ethanol in which simply stirring the primary amine & aldehyde in ethanol & cooling the reaction mixture , one can get the product.

Hi there. In general, hydrazones can be synthesized in etoh or meoh with acetic acid if the starting materials are soluable in hot etoh or meoh.

I have hydrazide type starting compound which is soluable in DMF or DMSO. I wonder whether using DMF or mixture of DMF/etoh as a solvent for the synthesis of hydrazone by the reaciton of aromatic aldehyde and hydrazide type compounds is suitable or not?

Thanks!

Please read the suggestion article by Dr. Sikandar Khan.