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Questions related from Luigi Grassi
The degradation pathways leading to Asn degradation are quite different from those of Asp (e.g. Asn is hydrolised at pH 1-4, is stable between pH 4-5 and undergoes general buffer catalised Asu...
20 November 2018 1,916 0 View
DEA treatment of an Fmoc protected peptide in solution caused degradation of the material as detected by analytical HPLC...has anybody any clue about what could be ever going on? Thank you for...
09 May 2015 1,157 3 View
literature references would be highly appreciated...thanks for the collaboration
19 March 2015 9,191 4 View
I am using the said reagent (0.5 eq) to cleave off the allyl Pg on resin, in presence of phenylsilane (25 eq) in DCM. After repeating the protocol 6 times for 20 min, the resin changed color,...
17 January 2015 5,208 7 View
I am attempting to convert the salicylaldehyde into the correspondent dimethyl acetal using the following procedure. I dissolve it in MeOH in presence of triethyl orthoformate and decaborane as...
02 December 2014 881 6 View
I would go for converting the NH into N2 then reaction with some source of SH...has anybody better ideas? (do not have the chance to use H2S)
04 November 2014 9,302 8 View
Could someone please give me any reference where I can find the UV spectra of salicylaldehyde? What influences would have the esterification of OH with a glycine lysine, on the UV/VIS behaviour?...
24 July 2014 660 3 View
Each cycle would be done with 2 treatments, 1 min each. Topic is phenyl esters hydrolysis.
08 July 2014 4,101 4 View
I tried to make the reaction with DCC DMAP or DCC/HOBT between a protected peptide with the protected Salicyl aldehyde (as dimethyl acetal). The first time it came more or less good, then when I...
06 May 2014 8,779 2 View
