Dear Sanaz,
Wikipedia might be a good starting point but I do not think it is an exhaustive source on chemical compounds when working in science. I would rather search PubChem database for aripiprazole
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60795&loc=ec_rcs
Here is the "Table of Contents" with all the information you can find on this compound and its definition below.
Good luck!
Identification and Related Records
Use and ManufacturingUse and Manufacturing
PharmacologyPharmacology
Biomedical Effects and ToxicityBiomedical Effects and Toxicity
Safety and HandlingSafety and Handling
Environmental Fate and Exposure PotentialEnvironmental Fate and Exposure Potential
Exposure Standards and RegulationsExposure Standards and Regulations
LiteratureLiterature
Biological Test ResultsBiological Test Results
ClassificationClassification
Chemical and Physical Properties
Aripiprazole is an atypical antipsychotic medication used for the treatment of schizophrenia. It has also recently received FDA approval for the treatment of acute manic and mixed episodes associated with bipolar disorder. Aripiprazole appears to mediate its antipsychotic effects primarily by partial agonism at the D2 receptor. In addition to partial agonist activity at the D2 receptor, aripiprazole is also a partial agonist at the 5-HT1A receptor, and like the other atypical antipsychotics, aripiprazole displays an antagonist profile at the 5-HT2A receptor. Aripiprazole has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors
Aripiprazole (brand name Abilify) is a partial dopamine agonist originally developed to treat schizophrenia, but is currently also being prescribed for other disorders such as depression. The primary difference between this drug and other antipsychotics is that this drug is a partial agonist rather than an antagonist. The thought being that in schizophrenia, in certain brain areas, such as the prefrontal cortex, there is too little dopamine while in other areas such as the striatum, there is too much. Rather than block dopamine altogether, this drug seeks to balance the levels over the whole brain.
Aripiprazole is an atypical medication introduced by Otsuka and marketed in the USA by BMS. One of the best source is wikipedia - and please make a donation since this site is an excellent site for everybody.
Aripiprazole is a most efficient and latest antipsychotic drug used to treat schizophrenia bipolar disorders.
it is a new generation drug for bipolar diseases... it is a D2 partial agonist...but unlike de oder class it has less extra-pyramidal effects and does nt cause weight gain
Hey!!
To all fellow unbiased thinkers, is aripiprazol contraindicated in old patients with dementia? If so can you highlight any specific reasons?
Hi Pritish here is one clue to answer your question, lets see what others think.
"Antipsychotic medications have a modest effect on the neuropsychiatric symptoms of dementia, but product labels warn of the excess risk of death and morbidity associated with their use in older patients. As such, these agents should not be the first choice for the treatment of behavioral and psychotic symptoms of dementia" Geriatrics. 2009 May;64(5):10-8. Update on neuropsychiatric symptoms of dementia: antipsychotic use. Kalapatapu RK, Schimming C.
"Experience in those 65 years of age and older insufficient to determine whether they respond differently from younger adults. Studies in patients with psychiatric symptoms in association with dementia of the Alzheimer's type have suggested that there may be a different tolerability profile in patients 65 years of age or older compared with younger patients with schizophrenia. Safety and efficacy of aripiprazole in the management of psychosis in association with dementia of the Alzheimer's type not established; use with caution."
[McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2005. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2005 (Plus Supplements)., p. 2295]
ARIPIPPRAZOL is an atypical antipsychotic and antidepressant used in the treatment of bipolar disorder, and clinical depression.
an atypical antipsychotic but is a partial dopamine D2 agonist rather than D2 anatagonist as are most other antipsychotics (typical and atypical). Other properties such as 5HT2A antagonism and 5HT1A partial agonism may contribute to its effects as an antipsychotic and as an antidperessant. I believe that it is approved in the US as an adjunct treatment for major depressive disorder in addition to being approved for the treatment of schizophrenia and manic/hypomanic episodes in bipolar disorder. It is also approved in many other countries for schizophrenia.
See the review by S. DHILLON, Aripiprazole (2012) Drugs 72 (1) 133-162
Sa beief descriptionof aripiprazole can be found in santos et al. (2020). Cost-effectiveness and Price of Aripiprazole for Schizophrenia in the Brazilian Public Health System. Journal of mental health policy and economics.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021436s038,021713s030,021729s022,021866s023lbl.pdf
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