Does anyone know if there is any formula I can use for calculation of a drug concentration (knowing oral dose) in small intestine and/or other parts of GI? Thanks
1. Yusei Miyamoto,Manabu HananoTatsujiIga, Masano buIshi-kawa. Concentration profile in the intestinal tract and drug absorption model: two-dimensional laminar flow in a circular porous tube; Journal of Theoretical Biology.102(4), 1983, 585-601
2. Levitt DG. Quantitation of small intestinal permeability during normal human drug absorption. BMC Pharmacology & Toxicology. 2013;14:34. doi:10.1186/2050-6511-14-34.
3. K. Sandy Pang.MODELING OF INTESTINAL DRUG ABSORPTION: ROLES OF TRANSPORTERS AND METABOLIC ENZYMES (FOR THE GILLETTE REVIEW SERIES).Drug Metabolism and Disposition December 2003, 31 (12) 1507-1519.