Well in my opinion its pertinent to happen in medical science when a single case or a case report is presented.

sometimes a direct physiological experiment is done on a single human subject, a volunteer or even the researcher him/her self.

this is to answer questions where animal studies are inconsistent.

two examples are: 1. ; blocking the vagus and glossopharyngeal nerves to test whether carotid body chemoreceptor responses are important in man

2.direct measurement of arterial PCO2 transients following transient CO2 breathing - again in carotid chemoreceptor studies in man,

see link attached and my RG site

J LEIGH

“Arterial PCO2 stimulus in transient CO2 tests of peripheral chemoreceptor function in man”

J App Physiol 66: 1013-4 (1989)

.Article Peripheral chemoreceptor block in man

Dear Dennis Mazur

I think if N=1 then it will a case report

Dennis,

with your RG of 45 and current employment of the Oregon Health and Science University this "question" can only be a test balloon to see how others expose themselves.

Let me know what has come out.

Best,

Dietrich Doll

N= 1 means sample of one . It directs towards case report

Well in my opinion its pertinent to happen in medical science when a single case or a case report is presented.

single case report

important as it may initiate and open doors for further new deeper researches .

Just remember the first case of AIDS when it occurred in the eighties. It was a case report that led later to the formulation of a hypothesis about the risk factors of AIDS.

Are you referring to the book n=1 ?

or follow the answer of Shebani A, Khan J, Zarak M and Adam I.?

A journey of a thousand miles begins with a single step.( Lao Tzu ) ?

N=1 is different that N=1st ?

Sorry to answer with questions ?

I will follow Lao Tzu .

Yes; with proper ethical , bring the imagination to reality.

Many considered 1 or first studies which are difference in evolution. Few are uniquely original.

Published as mentioned before by my colleagues . N=1 study must be proved the results with more evidence.

it will be better if Dennis provides some clarification about his concern on N=1 Study& N=1 studies?

The argument of N = 1 studies in medicine goes something like this: Randomized controlled trials (RCTs) give results that are relevant to the study participant studied. Research physicians argue that one must go beyond RCTs and conduct N=1 studies in each patient to determine if the study drug-1 that was shown to be better in the RCT is actually the best choice for the patient. In this N=1 study, the patient is randomized to study drug-1, alternative drug-2 already on the market, and placebo is a round about fashion to determine which of the three--study drug-1, alternative drug-2, or placebo--is the best treatment for the individual patient.

Dennis

Dennis Mazur

it means in case we conduct study on one subject or on with one sample size, it is n+1 stusy

It's not the the question of 1# sample. Statistically the sample size be enough representative in general analysis.

In case of medicine single , rare case is studied as case report and has nothing to do with sample size or sampling as it unique and have a single representation as CASE REPORT.

Just a short comment on n=1 patient. Agree with the comments above this may be a case report. I would also like to direct you to the everyday clinical practice. If there is n=1 patient with poor outcome, we are reviewing the case and, sometime, this may lead to changes in our clinical practice of our group such to avoid in the future those outcomes. Thus, either way, the N=1 is important. For your second question, we all are looking for original research, so most of newly published study will be N=1 studies on that respective topic until others come along.