I’m planning an in vivo study on the radioprotective effects of resveratrol in adult male C57BL/6 mice via daily oral gavage. In parallel, I will gavage a specific live strain of Lactobacillus plantarum. I would greatly appreciate practical advice and references on the following:

• Best vehicle for resveratrol: Is an aqueous 0.5% (w/v) carboxymethylcellulose (CMC) with 0.2% (w/v) Tween-80 appropriate? If ethanol is used to wet/dissolve resveratrol first, what is a safe maximum final % v/v ethanol in the dosing solution? Any experience with avoiding DMSO?
• Exact preparation steps (to ensure dispersion, stability, and reproducibility): Hydration of CMC and addition of Tween-80 (concentrations, mixing time, overnight swelling yes/no). Pre-wetting resveratrol with a minimal volume of ethanol (if recommended), then bringing to volume with the vehicle; target final ethanol %; mixing/sonication tips; protection from light. Recommended dose volume (mL/kg), viscosity considerations for gavage needles (20–22G), and whether to prepare fresh daily vs. prepare a batch and store (storage time/temperature). pH range and filtration advice (to avoid loss of drug on filters).
• Co-gavage with live L. plantarum: Preferred suspension medium for bacteria (e.g., sterile PBS or other) and typical dosing CFU per day. Should resveratrol and L. plantarum be delivered separately (e.g., 30–60 min apart) to avoid any antibacterial effects of ethanol/Tween-80? Any known interactions impacting bacterial viability or resveratrol absorption.
• Reporting details: examples of published methods (vehicle composition, final ethanol %, dose volume, storage, and light protection) that reviewers have accepted.