Hello,

If you designed a small molecule to disrupt either cysteine in the Heme-binding domain that would certainly alter the function...if that is your goal!

Best,

Yes Gregory, but I want the drug to be specific, being able to interact with the target peptide but not with other heme-proteins. Your further comments will be greatly appreciated.

I should suggest to search for an hydrophilic/antigenic/accessibility(β-turns) site, by a computer program, and then either making an antibody or try synthetic complement peptides.

Thanks Ioan. That sounds useful. Computer programs such as which.,?

Dear N Ivan,

I used to make use and develop such simple programs at ''80. However a long time has past since then ...

These sites may prove useful:

http://www.mybiosoftware.com/hydrophobicity-display-hydropathic-character-protein.html

https://molbiol-tools.ca/Protein_Chemistry.htm

https://www.google.com/search?q=protein+surface+accessibility+prediction&oq=protein+surface&sourceid=chrome&ie=UTF-8

If you have any trouble please ask.

Thanks Ioan, I'll visit those soon.