Hi all,

I am looking for drugs targeting neurological disorders and thus should cross the blood-brain barrier (BBB). However, when I run the molecule on ADMETlab 2.0, it shows Red (++) for BBB (Image attached). I am a little confused now whether this means that it can cross BBB or it is not good for consideration. The same confusion is with Toxicity. If I have to screen anti-cancer drugs, should I consider the toxicity as a good sign?

Thanks in advance for the help

Best

Shubham