Bambi is considered an antagonist of TGF-beta, when I give carbon tetrachloride injection to the bambi conditionally knockout mice 3 time times a week for 4 week the injury in the liver was found less severe then that of wildtype mice, principally I believe it might much severe then that of wildtype. Can anybody help me to come out from this confusion.
This is just a theory of mine.
Bambi attenuates TGF-β signaling by interfering with the heterocomplex formation of TGF-β receptors. When Bambi is absent TGF-β signaling occurs at its best. Since TGF-β regulates normal cell growth, development, and tissue remodeling following injury, I would expect that Bambi KO would indeed suffer a less severe effect than WT. In the same way, if it was a TGF-β KO or TGF-βR KO, I would expect it to suffr a more severe effect.
But again, this is a personal theory.
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