We can speculate that Na+/K+ ATPase stimulate or other pathways (such as energy metabolism) may activate to response this situation. Consequently, is it possible to promote cell proliferation?
Elizaveta Klimanova
@Yingjie Li, a change in the intracellular content of sodium ions can be mediated by Na,K-ATPase. Its inhibition, for example, leads to [Na+]i increase. This leads to a change in the transcription of a number of genes. An increase in proliferation may be mediated by Na,K-ATPase. However, this effect is associated rather with activation of the enzyme than with its inhibition.
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