I'm trying to activate beta cells in vivo acutely with Tolbutamide. This might sound trivial, but I found limited literature on the in vivo use of Tolbutamide.
The paper below reports use of 20ul of 5mM (analogous to 1.4 mg/kg) and 50ul of 10mM (analogous to 7mg/kg) Tolbutamide. Article Regulation by tolbutamide and diazoxide of the electrical ac...
They inject into vena cava and read out glycemia from abdominal aorta. I have tried injecting the same doses into the tail vein, but glycemia does not go down in my hands.I have not tried glibenclamide yet.
If you have experience using tolbutamide or glibenclamide in vivo, which concentrations do you use?
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